Biochemical Markers in Perinatal Asphyxia

Authors

  • Manisha Naithani Associate Professor, Department of Biochemistry, Sri Guru Ram Rai Institute of Medical Sciences, Deheradun
  • Ashish Kumar Simalti Graded Specialist in Paediatrics, Military Hospital, Agra.

Keywords:

S-100, Brain specific creatine kinase, neuron specific enolase, IL6, urinary uric acid, hypoxic ischaemic cerebral injury

Abstract

Early assessment of the severity of an acute cerebral lesion secondary to hypoxia-ischemia or other pathologic conditions may provide a very useful basis for preventive or therapeutic decisions in pediatric patients. In the present review, we discuss the diagnostic and prognostic value of a series of biochemical parameters, with special reference to the diagnosis of neonatal HIE. Currently many specific biochemical markers of brain injury are being investigated to assess regional brain damage after perinatal asphyxia in neonates of which serum protein S-100Ī², brain-specific creatine kinase, neuron-specific enolase, IL6 and urinary uric acid levels appear promising in identifying patients with a risk of developing hypoxic-ischemic encephalopathy. Whether detection of elevated serum concentrations of these proteins reflects long-term neurodevelopmental impairment remains to be investigated.

Key words: S-100; Brain specific creatine kinase; neuron specific enolase; IL6; urinary uric acid; hypoxic ischaemic cerebral injury.

DOI: 10.3126/jnps.v31i2.4155

J Nep Paedtr Soc 2010;31(2):151-156

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Published

2011-05-06

Issue

Vol. 31 No. 2 (2011)

Section

Personal Practice